Xanthine oxidoreductase is present in human synovium.

Regulation of the Human Xanthine Oxidoreductase Gene

Expression and Regulation of Human Xanthine Oxidoreductase

Yliopistopaino The truth is rarely pure and never simple.

Human xanthine oxidoreductase: in search of a function.

The molybdoenzyme, xanthine oxidoreductase (XOR), has been much studied, largely because of its ready availability on a large scale from cows' milk [ l ] . It catalyses the oxidation of a wide range of substrates, most notably hypoxanthine and xanthine, generating xanthine and uric acid respectively, in the process of purine catabolism. The enzyme is a homodimer of 150 kDa subunits and exists i...

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.

Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Here we have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid. Although normal at birth, XOR-/- mice fail to thrive after 10 to 14 days, and most die within the first ...

Human xanthine oxidoreductase determination by a competitive ELISA.

1 Human Xanthine Oxidoreductase Determination by a Competitive ELISA Maria Giulia Battelli and Silvia Musiani .............................................. 3 2 Simultaneous Determination of Polyunsaturated Fatty Acids and Corresponding Monohydroperoxy and Monohydroxy Peroxidation Products by HPLC Richard W. Browne and Donald Armstrong ..................................... 13 3 Determination of...